BDBM50018830 CHEMBL3286830::US10543199, Compound PF-06463922::US10780082, Compound PF-06463922::US11517561, Compound PF-06463922

SMILES C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nn(C)c2C#N

InChI Key InChIKey=IIXWYSCJSQVBQM-LLVKDONJSA-N

Data  13 KI  65 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50018830   

TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataKi: <0.0200nMAssay Description:Inhibition of ROS1 (unknown origin) by off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataKi: <0.0250nMAssay Description:Inhibition of wild type ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataKi: <0.0250nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of ROS1 L2026M mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataKi:  12nMAssay Description:Inhibition of ROS1 G2032R mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed